Stimulator of interferon genes protein (IPR029158)

Short name: STING

Overlapping homologous superfamilies


Family relationships



Transmembrane protein 173, also known as stimulator of interferon genes protein (STING) or endoplasmic reticulum interferon stimulator (ERIS), is a transmembrane adaptor protein which is involved in innate immune signalling processes. It induces expression of type I interferons (IFN-alpha and IFN-beta) via the NF-kappa-B and IRF3, pathways in response to non-self cytosolic RNA and dsDNA [PMID: 18724357, PMID: 19776740, PMID: 18818105, PMID: 19433799].

GO terms

Biological Process

GO:0002218 activation of innate immune response
GO:0032481 positive regulation of type I interferon production

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.