3-hydroxyisobutyrate dehydrogenase, NAD-binding domain (IPR029154)

Short name: NADP-bd

Overlapping homologous superfamilies

Domain relationships



3-Hydroxyisobutyrate is a central metabolite in the valine catabolic pathway, and is reversibly oxidised to methylmalonate semi-aldehyde by a specific dehydrogenase belonging to the 3-hydroxyacid dehydrogenase family. This entry represents the NAD-binding domain of 6-phosphogluconate dehydrogenase that adopts a Rossmann fold [PMID: 16126223].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0051287 NAD binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.