Homologous Superfamily

Creatinase/Aminopeptidase P/Spt16, N-terminal (IPR029149)

Short name: Creatin/AminoP/Spt16_NTD

Overlapping entries


This entry represents the N-terminal domain of creatinase and aminopeptidase P, and the N-terminal lobe domain of the FACT complex subunit Spt16.

Creatinase or creatine amidinohydrolase (EC: catalyses the conversion of creatine and water to sarcosine and urea. The enzyme works as a homodimer, and is induced by choline chloride. Each monomer of creatinase has two clearly defined domains, a small N-terminal domain, and a large C-terminal domain.

The structure of the N-terminal domain of creatinase is similar to N-terminal domain of aminopeptidase P (X-Pro aminopeptidase I,II and III EC: and related sequences belonging to the peptidase M24B family.

Yeast facilitator of chromatin transcription complex (FACT) is a heterodimer (composed of Spt16 and Pob3) that associates with chromatin via interaction with Nhp6A and Nhp6B proteins. In Spt16, the N-terminal lobe of the NTD (N-terminal domain) acts as a protein-protein interaction domain presumably with partners outside of the FACT complex [PMID: 18089575].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.