Small proline-rich protein 2 (IPR029142)

Short name: SPRR2

Overlapping homologous superfamilies


Family relationships


Small proline-rich (SPRR) proteins are structural components of the cornified cell envelope of stratified squamous epithelia. They are subdivided into three families: SPRR1, SPRR2, and SPRR3 [PMID: 9888996].

This entry represents SPRR2, a family of small proteins rich in proline, cysteine and glutamate. They contain a tandemly repeated nonamer, PKCPEPCPP [PMID: 3133554]. They are components of the cornified envelope of keratinocytes [PMID: 11279051].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0001533 cornified envelope

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.