Developmental pluripotency-associated protein 3 (IPR029096)

Short name: Dppa3

Overlapping homologous superfamilies


Family relationships



Dppa3 (developmental pluripotency-associated protein 3), also known as Stella or PGC7, belongs to family known only in placental mammals [PMID: 14654002, PMID: 14990856, PMID: 17143267]. The PGC7/Stella/Dppa3 protein protects imprinted regions from demethylation post-fertilization [PMID: 17143267]. This suggests that it might bind methylated DNA sequences directly [PMID: 21507349]. Dppa3 also seems to be involved in the demethylation process during reprogramming of embryonic germ cell precursors [PMID: 23595900]. Most placental mammals contain 3-6 paralogues of this family.

The conserved core of Dppa3 includes a positively charged helical segment and a C-terminal CXCXXC motif that is predicted to chelate a metal ion [PMID: 21507349]. The CXCXXC motif is also conserved in a subset of fungal MBD4-like proteins [PMID: 21507349].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0035064 methylated histone binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.