ZW10 interactor (IPR029092)

Short name: Zwint-1

Family relationships



ZW10 interactor (also known as Zwint-1) is part of the MIS12 complex, which is required for kinetochore formation and spindle checkpoint activity [PMID: 15485811]. It recruits ZW10 to unattached kinetochores at prometaphase [PMID: 16732327]. It is essential for stable binding of a Mad1-Mad2 complex to unattached kinetochores [PMID: 15824131]. It can be phosphoryltated by Aurora B (AurB) kinase [PMID: 21775627].

GO terms

Biological Process

GO:0007093 mitotic cell cycle checkpoint

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0000776 kinetochore

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.