Homologous Superfamily

Class I glutamine amidotransferase-like (IPR029062)

Short name: Class_I_gatase-like

Overlapping entries



This superfamily represents the class I glutamine amidotransferase-like domain.

Glutamine amidotransferase (GATase) enzymes catalyse the removal of the ammonia group from glutamine and then transfer this group to a substrate to form a new carbon-nitrogen group [PMID: 4355768]. The GATase domain exists either as a separate polypeptidic subunit or as part of a larger polypeptide fused in different ways to a synthase domain. Two classes of GATase domains have been identified [PMID: 3298209, PMID: 6086650]: class-I (also known as trpG-type or triad) and class-II (also known as purF-type or Ntn). In class I glutamine amidotransferases, a triad of conserved Cys-His-Glu forms the active site, wherein the catalytic cysteine is essential for the amidotransferase activity [PMID: 8548458, PMID: 9575335]. Different structures show that the active site Cys of type 1 GATase is located at the tip of a nucleophile elbow.

This entry also include the DJ-1/PfpI protein that contains a catalytic triad or dyad different from the class I GAT triad.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.