Homologous Superfamily

PIN-like domain superfamily (IPR029060)

Short name: PIN-like_dom_sf

Overlapping entries


This superfamily represents a domain sharing protein structural similarity with the PIN domain. This domain can also be found in the N-terminal of the 5'3'-exonuclease, which has a 3-layer alpha/beta/alpha core structure and contains an alpha-helical arch [PMID: 8657312].

PIN domains are small protein domains identified by the presence of three strictly conserved acidic residues. Apart from these three residues, there is poor sequence conservation [PMID: 21036780]. PIN domains are found in eukaryotes, eubacteria and archaea. In eukaryotes they are ribonucleases involved in nonsense mediated mRNA decay [PMID: 17053788] and in processing of 18S ribosomal RNA [PMID: 19706509]. In prokaryotes, they are the toxic components of toxin-antitoxin (TA) systems, their toxicity arising by virtue of their ribonuclease activity. The PIN domain TA systems are now called VapBC TAs(virulence associated proteins), where VapB is the inhibitor and VapC, the PIN-domain ribonuclease toxin [PMID: 21036780].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.