Homologous Superfamily

Heat shock protein 70kD, C-terminal domain superfamily (IPR029048)

Short name: HSP70_C_sf

Overlapping entries


Members of the 70-kilodalton heat-shock protein (HSP70) family promote protein folding both constitutively and in response to stress. These proteins have two functional units: a substrate-binding unit, and an adenosine triphosphatase unit. The substrate-binding unit of DnaK consists of a beta-sandwich domain followed by alpha-helical segments. The alpha-helical domain stabilises the complex, but does not contact the peptide directly [PMID: 8658133].

This superfamily represents the C-terminal alpha-helical subdomain of the substrate-binding unit from DnaK and other HSP70 proteins.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.