Homologous Superfamily

Caspase-like domain superfamily (IPR029030)

Short name: Caspase-like_dom_sf

Overlapping entries


This superfamily represents the caspase-like domain found in caspases, metacaspases and peptidases of the C25 family (gingipains).

Caspases (Cysteine-dependent ASPartyl-specific proteASE) are cysteine peptidases [PMID: 11517925]. They are tightly regulated proteins that require zymogen activation to become active, and once active can be regulated by caspase inhibitors. Caspases are mainly involved in mediating cell death (apoptosis) [PMID: 10578171, PMID: 10872455, PMID: 15077141]. They have two main roles within the apoptosis cascade: as initiators that trigger the cell death process, and as effectors of the process itself. Caspases can have roles other than in apoptosis, such as caspase-1 (interleukin-1 beta convertase) (EC:, which is involved in the inflammatory process. The activation of apoptosis can sometimes lead to caspase-1 activation, providing a link between apoptosis and inflammation, such as during the targeting of infected cells. Caspases may also be involved in cell differentiation [PMID: 15066636].

Metacaspases are arginine/lysine-specific, in contrast to caspases, which are aspartate-specific. They are found only in plants [PMID: 17998208, PMID: 23522353], fungi [PMID: 18355456] and lower eukaryotes, including the protozoa [PMID: 23506317]. While plant metacaspases have been shown to be involved in cell death pathways, in other organisms they have evolved alternative functions [PMID: 21949125].

Lys-gingipains are cysteine proteinases with a strong preference for substrates with Lys in the P1 position [PMID: 15576324].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.