CENP-S/Mhf1 (IPR029003)

Short name: CENP-S/Mhf1

Overlapping homologous superfamilies

Family relationships


This entry includes animal centromere protein S (CENP-S) and its yeast homologue, Mhf1. CENP-S/Mhf1 is a component of the FANCM-MHF complex, an essential DNA-remodeling complex that protects replication forks in response to DNA damage [PMID: 20347428, PMID: 24026537, PMID: 24256282]. FANCM-MHF promotes gene conversion at blocked replication forks, probably by reversal of the stalled fork [PMID: 20347428, PMID: 24026537].

CENP-S is a dual function protein. It aids DNA repair/recombination and localises to centromeres to promote chromosome segregation [PMID: 24256282]. It is a kinetochore component that forms complexes with CENP-X to form a stable CENP-T-W-S-X heterotetramer [PMID: 20702077, PMID: 22304917].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0071821 FANCM-MHF complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.