Domain

Phospholipase C/D (IPR029002)

Short name: PLPC/GPLD1

Domain relationships

None.

Description

This domain is found in bacterial zinc-dependent phospholipase C and in eukaryotic phosphatidylinositol-glycan-specific phospholipase D.

Bacterial phospholipase C is a zinc-dependent enzyme, binding 3 zinc ions per molecule [PMID: 2111259]. This enzyme catalyses the conversion of phosphatidylcholine and water to 1,2-diacylglycerol and choline phosphate. Phosphatidylinositol-glycan-specific phospholipase D is an extracellular amphiphilic glycoprotein [PMID: 1606959, PMID: 2017684]. It hydrolyses the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans, releasing these proteins from the membrane.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam