Phospholipase C/D (IPR029002)

Short name: PLPC/GPLD1

Overlapping homologous superfamilies


Domain relationships



This domain is found in bacterial zinc-dependent phospholipase C and in eukaryotic phosphatidylinositol-glycan-specific phospholipase D.

Bacterial phospholipase C is a zinc-dependent enzyme, binding 3 zinc ions per molecule [PMID: 2111259]. This enzyme catalyses the conversion of phosphatidylcholine and water to 1,2-diacylglycerol and choline phosphate. Phosphatidylinositol-glycan-specific phospholipase D is an extracellular amphiphilic glycoprotein [PMID: 1606959, PMID: 2017684]. It hydrolyses the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans, releasing these proteins from the membrane.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.