Family

Inosine triphosphate pyrophosphatase-like (IPR029001)

Short name: ITPase-like_fam

Family relationships

Description

This entry represents the inosine triphosphate pyrophosphatase (ITPase)-like proteins. Members in this family include NTPases, such as Ham1-like protein (non-canonical purine NTP pyrophosphatase) and non-canonical purine NTP phosphatase (YjjX-like), and some proteins with unknown function, such as Maf-like protein and PRRC1 protein.

Non-canonical purine NTP phosphatases are prokaryotic phosphatases that hydrolyse non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives [PMID: 16216582].

Ham1 is a pyrophosphatase that hydrolyses the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and 5-bromodeoxyuridine 5'-triphosphate (BrdUTP) to their respective monophosphate derivatives [PMID: 22531138].

Maf is a putative inhibitor of septum formation in eukaryotes, bacteria, and archaea. Proline-rich and coiled-coil-containing protein 1 (PRRC1) is a Golgi-associated protein of unknown function [PMID: 15541471].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
SUPERFAMILY
GENE3D