Hedgehog/Intein (Hint) domain (IPR028992)

Short name: Hedgehog/Intein_dom

Overlapping homologous superfamilies

Domain relationships


This entry represents a domain found in the pretoxin HINT domain protein and the C-terminal of protein hedgehog.

Hedgehog proteins are a family of secreted signal molecules required for embryonic cell differentiation. They are synthesised as inactive precursors with an N-terminal signalling domain linked to a C-terminal autoprocessing domain. The three-dimensional structure of the autoprocessing domain shows similarity with the beta-strand core of intein splicing domains. It has hence been termed the Hedgehog/Intein (Hint) domain [PMID: 9489693].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.