InterPro

This entry represents a domain found in the pretoxin HINT domain protein and the C-terminal of protein hedgehog.

Hedgehog proteins are a family of secreted signal molecules required for embryonic cell differentiation. They are synthesised as inactive precursors with an N-terminal signalling domain linked to a C-terminal autoprocessing domain. The three-dimensional structure of the autoprocessing domain shows similarity with the beta-strand core of intein splicing domains. It has hence been termed the Hedgehog/Intein (Hint) domain [PMID: 9489693].