WRB/Get1 family (IPR028945)

Short name: WRB/Get1

Overlapping homologous superfamilies


Family relationships


In budding yeasts, Golgi to ER traffic protein 1 (Get1) is a component of the Golgi to ER traffic (GET) complex, which is composed of Get1, Get2 and Get3. The GET complex mediates posttranslational insertion of newly synthesised tail-anchored (TA) proteins to the endoplasmic reticulum (ER) membrane.The GET complex is composed of the homodimeric Get3 ATPase and its heterooligomeric receptor, Get1/2. Get1 stabilises an open dimer conformation of Get3 [PMID: 22684149].

In metazoa, the homologue to Get1 is known as tail-anchored protein insertion receptor WRB, which is a receptor for ASNA1/TRC40 (Get3 in yeast) [PMID: 21444755].

GO terms

Biological Process

GO:0071816 tail-anchored membrane protein insertion into ER membrane

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.