WHIM1 domain (IPR028942)

Short name: WHIM1_dom

Overlapping homologous superfamilies


Domain relationships



WHIM1 is a conserved alpha helical motif that along with the WHIM2 and WHIM3 motifs, and the DDT domain comprise an alpha helical module found in diverse eukaryotic chromatin proteins [PMID: 22186017].Based on the Ioc3 structure, this module is inferred to interact with nucleosomal linker DNA and the SLIDE domain of ISWI proteins [PMID: 22186017, PMID: 21525927]. The resulting complex forms a protein ruler that measures out the spacing between two adjacent nucleosomes [PMID: 21525927]. The conserved basic residue in WHIM1 is involved in packing with the DDT motif. The module shows a great domain architectural diversity and is often combined with other modified histone peptide recognizing and DNA binding domains, some of which discriminate methylated DNA [PMID: 22186017].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.