Family

Bromodomain adjacent to zinc finger domain protein 2A (IPR028940)

Short name: TIP5

Family relationships

None.

Description

Bromodomain adjacent to zinc finger domain protein 2A (BAZ2A, also known as TIP5) and ATPase SNF2h form the nucleolar remodeling complex (NoRC), which mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing [PMID: 16085498, PMID: 20168299]. TIP5 contains a C-terminal bromodomain, which is found in many chromatin-associated proteins and has been shown to bind to acetylated histone tails. The bromodomain cooperates with an adjacent PHD finger to recruit HDAC1, DNMT1, DNMT3, and SNF2h to rDNA [PMID: 16085498].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER