Remodeling and spacing factor 1 (IPR028938)

Short name: Rsf-1

Overlapping homologous superfamilies


Family relationships



Remodelling and spacing factor 1 (Rsf-1, also known as HBXAP) and SNF2h ATPase form the RSF chromatin remodelling complex [PMID: 20923775]. Rsf-1 can induce chromosomal instability and is overexpressed in many types of cancer cells [PMID: 22528946, PMID: 22387541, PMID: 22569540]. Its overexpression induces DNA damage response through ATM-Chk2-p53-p21 pathway [PMID: 24351651]. It also interacts and collaborates with cyclin E1 in tumour development [PMID: 23378270].

Rsf-1 is identical to the largest isoform of HBXAP (HBXAPalpha/Rsf-1), which interacts with hepatitis B virus X protein (HBx). HBXAP may function as a negative regulator for TNF-alpha-induced, NF-kappaB-mediated gene activation [PMID: 15242768].

GO terms

Biological Process

GO:0006355 regulation of transcription, DNA-templated

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0031213 RSF complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.