CENP-C, middle DNMT3B-binding domain (IPR028931)

Short name: CENP-C_mid

Overlapping homologous superfamilies


Domain relationships



CENP-C is a component of the centromere assembly complex in eukaryotes. CENP-C recruits the DNA methyltransferases DNMT3B, in order to establish the necessary epigenetic DNA-methylation essential for maintenance of chromatin structure and genomic stability. This entry represents the middle DNMT3B binding region of CENP-C. Binding of CENP-C and DNMT3B to DNA occurs at both centromeric and peri-centromeric satellite repeats. CENP-C and DNMT3B regulate the histone code in these regions [PMID: 1, PMID: 2].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.