Domain

Tox-GHH domain (IPR028916)

Short name: Tox-GHH_dom

Domain relationships

None.

Description

This entry represents the HNH/Endonuclease VII fold present in bacterial polymorphic toxin systems with a characteristic sG[HQ]H signature motif. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 6, type 7 or TcdB/TcaC-type secretion system [PMID: 22731697].

In animals, an inactive version of the GHH domain can be found in the C-terminal of teneurin and Odd Oz proteins [PMID: 22731697].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam