Ubiquitin-specific peptidase-like, SUMO isopeptidase (IPR028890)

Short name: Peptidase_C98

Overlapping homologous superfamilies


Domain relationships


Peptidase C98 is a small family of SUMO - small ubiquitin-related modifier - isopeptidases found in eukaryotes. Reversible attachment of SUMO is an essential protein modification in all eukaryotic cells. SUMO-specific isopeptidase USPL1 neither binds nor cleaves ubiquitin, but is a potent SUMO isopeptidase. The invariant residues required for SUMO binding and cleavage, in Q5W0Q7 are Cys-236, His-456 and Asp-472, all of which are fully conserved in the family. Member proteins are low-abundance proteins that colocalise with coilin in Cajal bodies. Peptidase C98 depletion does not affect global sumoylation, but causes striking coilin mis-localisation and impairs cell proliferation, functions that are not dependent on the catalytic activity. Thus, Peptidase C98 represents a third type of SUMO protease, with essential functions in Cajal body biology [PMID: 22878415].

This entry represents the catalytic domain.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0032183 SUMO binding
GO:0070140 SUMO-specific isopeptidase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.