Molybdenum cofactor sulfurase (IPR028886)

Short name: MoCo_sulfurase

Overlapping homologous superfamilies


Family relationships



Molybdenum cofactor sulfurase sulfurates the molybdenum cofactor (MoCo). Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by one oxygen and one sulfur atom in active form [PMID: 18258600, PMID: 11553608, PMID: 15561708, PMID: 11029694, PMID: 12650690, PMID: 11302742]. This entry also includes its plant homologue, LOS5/ABA3. In plants, the sulfurylated MoCo is a cofactor of ABA-aldehyde oxidase that functions in the last step of ABA biosynthesis [PMID: 23326325].

GO terms

Biological Process

GO:0006777 Mo-molybdopterin cofactor biosynthetic process

Molecular Function

GO:0008265 Mo-molybdopterin cofactor sulfurase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.