tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit (IPR028884)

Short name: Trm82

Overlapping homologous superfamilies


Family relationships



This entry represents tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit Trm82 and its homologues, wuho from flies and WDR4 from humans.

In Saccharomyces cerevisiae, Trm82 is the noncatalytic subunit of the tRNA methyltransferase complex consists of Trm8 and Trm82 [PMID: 18184583, PMID: 17382321]. It is essential for the enzyme activity and may function in regulating the the Trm8 protein [PMID: 18184583].

In humans, WDR4 forms the tRNA methyltransferase complex with METTL1 (Trm8 homologue). It is required to stabilise and induce conformational changes of the catalytic subunit METTL1 [PMID: 12403464].

GO terms

Biological Process

GO:0036265 RNA (guanine-N7)-methylation

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.