Contactin-associated protein 1 (IPR028872)

Short name: Caspr1

Overlapping homologous superfamilies


Family relationships



Contactin-associated protein 1 (also known as paranodin or caspr1) has a key role in the formation of the paranodal junctions and is required for normal saltatory conduction [PMID: 11395000]. It seems to demarcate the paranodal region of the axo-glial junction. In association with contactin, it may have a role in the signaling between axons and myelinating glial cells [PMID: 9118959, PMID: 9292722, PMID: 9396755, PMID: 9786343]. It also plays a role in regulating of the trafficking of AMPA receptors to synapses [PMID: 22223644].

GO terms

Biological Process

GO:0030913 paranodal junction assembly

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0016021 integral component of membrane
GO:0033270 paranode region of axon

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.