Neuropilin and tolloid-like protein 2 (IPR028868)

Short name: NETO2

Overlapping homologous superfamilies


Family relationships



Neuropilin and tolloid-like protein 1 (Neto1) and 2 (Neto2) share an identical and unique domain structure representing a new subfamily of transmembrane proteins containing CUB (complement C1r/C1s, Uegf, Bmp1) and LDLa (low-density lipoprotein receptor class A) domains [PMID: 11943477]. Neto1 and Neto2 display a complementary expression profile in the mouse brain [PMID: 12810072, PMID: 15464227]. Fast excitatory synaptic transmission in the vertebrate brain is mediated by three classes of ionotropic glutamate receptors: AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid) receptors (AMPARs), NMDA (N-methyl-d-aspartate) receptors (NMDARs), and kainate receptors (KARs). Neto1 and Neto2 auxiliary subunits associate with kainate receptors (KARs) to modulate its function [PMID: 24403160, PMID: 22431337]. Some studies also show that Neto1 and Neto2 associate with NMDA receptors (NMDARs) [PMID: 12810072,PMID: 24403160], while one study does not [PMID: 21623363].

Neto2 increases kainate-receptor channel activity, slowing the decay kinetics of the receptors [PMID: 19217376].

GO terms

Biological Process

GO:2000312 regulation of kainate selective glutamate receptor activity

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.