Cyclin-O (IPR028864)

Short name: Ccno

Overlapping homologous superfamilies

Family relationships



Cyclins are eukaryotic proteins that play an active role in controlling nuclear cell division cycles, and regulate cyclin dependent kinases (CDKs) [PMID: 12910258].

This entry represents cyclin-O. In mouse oocytes, it regulates maturation-promoting factor (MPF), which affects oocyte meiotic resumption [PMID: 23515676]. It is required to activate Cdk2 during apoptosis induced by intrinsic stimuli in lymphoid cells [PMID: 19609756]. Its activity is modulated by p53 and members of the Bcl-2 protein family [PMID: 19609756]. This entry also includes cyclin-O protein A/B, also known as CCNO, from Xenopus laevis. Mutations in CCNO result in congenital mucociliary clearance disorder with reduced generation of multiple motile cilia [PMID: 24747639].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.