Family

Cyclin-T1 (IPR028863)

Short name: CCNT1

Family relationships

None.

Description

Cyclins are eukaryotic proteins that play an active role in controlling nuclear cell division cycles [PMID: 12910258], and regulate cyclin dependent kinases (CDKs). This entry represents cyclin-T1 from vertebrates.

Cyclin-T associates with CDK9. Both cyclin-T and CDK9 are subunits of the positive-transcription elongation factor (P-TEFb), which facilitates transcription elongation by phosphorylating the carboxy-terminal domain (CTD) of the largest subunit of pol II [PMID: 10574912]. In humans, there are three T-type cyclins: cyclins T1, T2a and T2b. Cyclins T2a and T2b are splice variants of a primary transcript [PMID: 15276198]. Each of the T-type cyclin/CDK9 complexes can phosphorylate the C-terminal domain of the large subunit of RNA polymerase II. However, only human cyclin T1/CDK9 complexes can bind HIV Tat and promote RNA Pol II activation, allowing transcription of viral genes [PMID: 15276198, PMID: 16109377, PMID: 18655042, PMID: 23110726].

GO terms

Biological Process

GO:0006351 transcription, DNA-templated

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER