Family

Cyclin-T2 (IPR028862)

Short name: CCNT2

Family relationships

None.

Description

Cyclins are eukaryotic proteins that play an active role in controlling nuclear cell division cycles, and regulate cyclin dependent kinases (CDKs) [PMID: 12910258].

This entry represents cyclin-T2. It is a regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFB), which facilitates the transition from abortive to production elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNAP II) [PMID: 10364329]. Cyclin-T2 contains two domains that target RNAPII, and this substrate recognition is necessary for its transcriptional activity via DNA [PMID: 15563843]. In mice, cyclin-T2 is essential for embryogenesis [PMID: 19364821].

GO terms

Biological Process

GO:0006351 transcription, DNA-templated

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER