Cyclin-T2 (IPR028862)

Short name: CCNT2

Overlapping homologous superfamilies


Family relationships



Cyclins are eukaryotic proteins that play an active role in controlling nuclear cell division cycles, and regulate cyclin dependent kinases (CDKs) [PMID: 12910258].

This entry represents cyclin-T2. It is a regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFB), which facilitates the transition from abortive to production elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNAP II) [PMID: 10364329]. Cyclin-T2 contains two domains that target RNAPII, and this substrate recognition is necessary for its transcriptional activity via DNA [PMID: 15563843]. In mice, cyclin-T2 is essential for embryogenesis [PMID: 19364821].

GO terms

Biological Process

GO:0006351 transcription, DNA-templated

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.