Receptor-type tyrosine-protein phosphatase H (IPR028855)

Short name: R-PTP-H

Overlapping homologous superfamilies


Family relationships



Protein tyrosine phosphatases (PTPs) constitute a large and structurally diverse family of enzymes that are involved in the pathogenesis of a number of human diseases, such as cancer, diabetes, and autoimmune diseases. The classical PTPs possess at least one catalytic PTP domain and can be classified into transmembrane receptor-like PTPs (RPTPs) and non-transmembrane PTPs, based on their overall structure [PMID: 15186772].

This entry represents transmembrane receptor-like PTP H (RPTP-H, also known as Sap-1), which may contribute to contact inhibition of cell growth and motility by mediating the dephosphorylation of focal adhesion-associated substrates [PMID: 15850787] and thus negatively regulating integrin-promoted signalling processes [PMID: 11278335]. It can induce apoptotic cell death by at least two distinct mechanisms: inhibition of cell survival signaling mediated by PI 3-kinase, Akt, and ILK, and activation of a caspase-dependent proapoptotic pathway [PMID: 12101188].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0005001 transmembrane receptor protein tyrosine phosphatase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.