Mucin-16 (IPR028850)

Short name: MUC16

Overlapping homologous superfamilies


Family relationships



Mucin-16 (also known as CA125) belongs to the mucin family. They are high molecular weight proteins that are components of mucus and are synthesised and secreted by specialised cells of the epithelium (goblet cells, cells of mucous glands) or non mucin-secreting cells [PMID: 15190477].

Mucin-16 is over-expressed in human epithelial tumors including ovarian, breast and some other carcinomas [PMID: 21852110]. It interacts with Src family kinases (SFKs) and this may affect cell-cell adhesion of epithelial cancer cells [PMID: 24246580].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.