Family

Breast cancer anti-estrogen resistance protein 1 (IPR028848)

Short name: BCAR1

Overlapping homologous superfamilies

None.

Family relationships

  • CAS family (IPR037362)
    • Breast cancer anti-estrogen resistance protein 1 (IPR028848)

Description

Breast cancer anti-estrogen resistance protein 1 (BCAR1, also known as p130Cas) is a member of the Cas (Crk-associated substrate) family of adaptor proteins, which function as key signalling nodes with important regulatory roles in normal and pathological cells [PMID: 23277200, PMID: 19937461]. BCAR1 plays a central coordinating role for tyrosine kinase-based signalling through focal adhesion kinase (FAK) [PMID: 19822523]. It is readily phosphorylated by FAK and Src [PMID: 19822523]. Overexpression of BCAR1 confers anti-estrogen resistance on breast cancer cells [PMID: 16651418]. It regulates the tumour suppressor function of TGF-beta during breast cancer progression through regulation of Smad2/3 activity [PMID: 19822523].

GO terms

Biological Process

GO:0007165 signal transduction

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER