Family

Breast cancer anti-estrogen resistance protein 1 (IPR028848)

Short name: BCAR1

Family relationships

None.

Description

Breast cancer anti-estrogen resistance protein 1 (BCAR1, also known as p130Cas) is a member of the Cas (Crk-associated substrate) family of adaptor proteins, which function as key signalling nodes with important regulatory roles in normal and pathological cells [PMID: 23277200, PMID: 19937461]. BCAR1 plays a central coordinating role for tyrosine kinase-based signalling through focal adhesion kinase (FAK) [PMID: 19822523]. It is readily phosphorylated by FAK and Src [PMID: 19822523]. Overexpression of BCAR1 confers anti-estrogen resistance on breast cancer cells [PMID: 16651418]. It regulates the tumour suppressor function of TGF-beta during breast cancer progression through regulation of Smad2/3 activity [PMID: 19822523].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0004871 signal transducer activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER