Angiopoietin-4 (IPR028845)

Short name: Ang-4

Overlapping homologous superfamilies


Family relationships



Angiopoietins are the ligands of Tie-2 receptor, which is a vascular assembly and maturation-mediating receptor tyrosine kinase that controls blood vessel development. In humans, there are four identified angiopoietins, Ang-1, Ang-2, Ang-3 and Ang-4. They bind the first Ig-like loop plus the EGF-like repeats of Tie-2 whereby they activate Tie-2 and, indirectly, Tie-1 in Tie-1/Tie-2 heterodimers [PMID: 22922303, PMID: 12427764].

This entry represents angiopoietin-4 (Ang-4). Ang-4 induces angiogenesis in vivo using the mouse corneal micropocket assay [PMID: 15284220]. However, it inhibits angiogenesis induced by GLC19 tumor cells [PMID: 16790085].

GO terms

Biological Process

GO:0001525 angiogenesis

Molecular Function

GO:0030971 receptor tyrosine kinase binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.