Angiopoietin-2 (IPR028844)

Short name: Ang-2

Overlapping homologous superfamilies


Family relationships



Angiopoietins are the ligands of Tie-2 receptor, which is a vascular assembly and maturation-mediating receptor tyrosine kinase that controls blood vessel development. In humans, there are four identified angiopoietins, Ang-1, Ang-2, Ang-3 and Ang-4. They bind the first Ig-like loop plus the EGF-like repeats of Tie-2 whereby they activate Tie-2 and, indirectly, Tie-1 in Tie-1/Tie-2 heterodimers [PMID: 22922303, PMID: 12427764].

This entry represents angiopoietin-2 (Ang-2). Ang-2 is a partial agonist/antagonist of Tie-2 signalling in the endothelium [PMID: 19223473]. It plays an important role in angiogenesis during the development and growth of human cancers [PMID: 19216842]. It also play a part in inflammation-induced vascular remodeling [PMID: 22951441].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0030971 receptor tyrosine kinase binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.