Angiopoietin-1 (IPR028843)

Short name: Ang-1

Overlapping homologous superfamilies


Family relationships



Angiopoietins are the ligands of Tie-2 receptor, which is a vascular assembly and maturation-mediating receptor tyrosine kinase that controls blood vessel development. In humans, there are four identified angiopoietins, Ang-1, Ang-2, Ang-3 and Ang-4. They bind to the first Ig-like loop plus the EGF-like repeats of Tie-2, whereby they activate Tie-2 and, indirectly, Tie-1 in Tie-1/Tie-2 heterodimers [PMID: 22922303, PMID: 12427764].

This entry represents angiopoietin-1 (Ang-1). Ang-1 regulates the spatial localisation of Tie-2 and thereby affecting its downstream signalling [PMID: 22922303]. The angiopoietin-1/Tie-2 receptor signalling regulates both maintenance of vascular quiescence and promotion of angiogenesis [PMID: 20054809]. Ang-1 is stored at high levels in platelet granules [PMID: 11246533].

GO terms

Biological Process

GO:0048014 Tie signaling pathway
GO:0001525 angiogenesis

Molecular Function

GO:0030971 receptor tyrosine kinase binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.