Nuclear receptor coactivator 2 (IPR028822)

Short name: NCOA2

Overlapping homologous superfamilies


Family relationships


Nuclear receptor coactivator 2 (NCOA2, also known as Tif2) belongs to the SRC/p160 nuclear receptor coactivator family, which contains proteins that are ligand-dependent transcription factors [PMID: 10713439]. These receptors can function as molecular switches [PMID: 10713439].

NCOA2 is a transcriptional coactivator for steroid receptors and nuclear receptors. It functions as a coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1) [PMID: 9430642]. Together with NCOA1, it is required to control energy balance between white and brown adipose tissues [PMID: 12507421].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.