Nuclear receptor coactivator 1 (IPR028819)

Short name: NCOA1

Overlapping homologous superfamilies


Family relationships


Nuclear receptor coactivator 1 (NCOA1, also known as SRC-1) belongs to the SRC/p160 nuclear receptor coactivator family, which contains proteins that are ligand-dependent transcription factors [PMID: 10713439]. These receptors can function as molecular switches [PMID: 10713439].

NCOA1 directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion [PMID: 9427757]. It is involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs) [PMID: 10713439]. It is also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors [PMID: 11773079, PMID: 12954634, PMID: 12138096]. It plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors [PMID: 10449719]. It can be regulated by sumoylation and ubiquitination [PMID: 12529333].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.