Nucleobindin-2 (IPR028813)

Short name: NUCB2

Overlapping homologous superfamilies


Family relationships



Nucleobindin-2 (also known as NEFA) is a calcium-binding protein that may have a role in calcium homeostasis [PMID: 11749975, PMID: 7811391]. It can be cleaved into an isoform named nesfatin-1, which is an anorexigenic peptide that seems to play an important role in hypothalamic pathways regulating food intake and energy homeostasis, acting in a leptin-independent manner [PMID: 17036007, PMID: 22293188].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0005509 calcium ion binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.