Cell cycle and apoptosis regulator protein 2 (IPR028811)

Short name: CCAR2

Overlapping homologous superfamilies


Family relationships


Cell cycle and apoptosis regulator protein 2 (CCAR2, also known as DBC-1) regulates biological processes such as transcription, heterochromatin formation, metabolism, mRNA splicing, apoptosis, and cell proliferation [PMID: 23352644]. It is a core component of the DBIRD complex, which affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions [PMID: 23352644]. It binds to SIRT1 and is a negative regulator of SIRT1 [PMID: 18235501]. DBC-1 has been implicated in tumorigenesis [PMID: 19657230].

GO terms

Biological Process

GO:0008380 RNA splicing
GO:0043065 positive regulation of apoptotic process

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0044609 DBIRD complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.