SSX family (IPR028804)

Short name: SSX

Overlapping homologous superfamilies


Family relationships



This entry represents the SSX family, including SSX1-9. They are identified as cancer testis antigens and can act as a transcription modulator. Some members of this family can become fused to the SS18 protein in synovial sarcoma (SS) through gene translocations [PMID: 20981248]. In humans, SSX1-9 have a N-terminal KRAB (Kr├╝ppel-associated box) domain and a C-terminal RD (repression domain). The RD domain mediates repression of transcription and can be translocated to the C-terminal end of SYT in synovial sarcoma [PMID: 23686668].

GO terms

Biological Process

GO:0006355 regulation of transcription, DNA-templated

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.