Family

SSX (IPR028804)

Short name: SSX

Family relationships

None.

Description

This entry represents the SSX family, including SSX1-9. They are identified as cancer testis antigens and can act as a transcription modulator. Some members of this family can become fused to the SS18 protein in synovial sarcoma (SS) through gene translocations [PMID: 20981248]. In humans, SSX1-9 have a N-terminal KRAB (Kr├╝ppel-associated box) domain and a C-terminal RD (repression domain). The RD domain mediates repression of transcription and can be translocated to the C-terminal end of SYT in synovial sarcoma [PMID: 23686668].

GO terms

Biological Process

GO:0006355 regulation of transcription, DNA-templated

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER