Voltage gated sodium channel, alpha-9 subunit (IPR028803)

Short name: SCN9A

Overlapping homologous superfamilies


Family relationships


Nine voltage-gated sodium channels (Navs) are expressed in complex patterns in mammalian nerve and muscle. These channels mediate the influx of Na+ ions in response to local depolarising stimuli. Nav channels are composed of a pore-forming alpha-subunit associated with one or more auxiliary beta-subunits. The pore-forming alpha subunit is sufficient for functional expression, but the localisation, kinetics and voltage dependence of channel gating are modified by the beta subunits [PMID: 10798388, PMID: 16382098].

Sodium channel protein type 9 subunit alpha (also known as Nav1.7 or SCN9A) is strongly expressed in nociceptive neurons and plays a role in pain mechanisms, especially in the development of inflammatory pain [PMID: 15314237, PMID: 17167479, PMID: 20635406]. It interacts with the ubiquitin-protein ligases Nedd4 and Nedd4-2, known to regulate receptors and ion transporters [PMID: 15123669].

GO terms

Biological Process

GO:0048266 behavioral response to pain
GO:0006954 inflammatory response

Molecular Function

GO:0005248 voltage-gated sodium channel activity

Cellular Component

GO:0001518 voltage-gated sodium channel complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.