Voltage gated sodium channel, alpha-9 subunit (IPR028803)
Short name: SCN9A
Overlapping homologous superfamilies
- Voltage gated sodium channel, alpha subunit (IPR001696)
- Voltage gated sodium channel, alpha-9 subunit (IPR028803)
Nine voltage-gated sodium channels (Navs) are expressed in complex patterns in mammalian nerve and muscle. These channels mediate the influx of Na+ ions in response to local depolarising stimuli. Nav channels are composed of a pore-forming alpha-subunit associated with one or more auxiliary beta-subunits. The pore-forming alpha subunit is sufficient for functional expression, but the localisation, kinetics and voltage dependence of channel gating are modified by the beta subunits [PMID: 10798388, PMID: 16382098].
Sodium channel protein type 9 subunit alpha (also known as Nav1.7 or SCN9A) is strongly expressed in nociceptive neurons and plays a role in pain mechanisms, especially in the development of inflammatory pain [PMID: 15314237, PMID: 17167479, PMID: 20635406]. It interacts with the ubiquitin-protein ligases Nedd4 and Nedd4-2, known to regulate receptors and ion transporters [PMID: 15123669].
- PTHR10037:SF221 (PTHR10037:SF221)