Protein SMG8 (IPR028802)

Short name: SMG8

Overlapping homologous superfamilies


Family relationships

  • Smg8/Smg9 (IPR019354)
    • Protein SMG8 (IPR028802)


SMG8 is involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. In humans, it is a component of the SMG1C complex composed of SMG1, SMG8 and SMG9 [PMID: 19417104]. SMG-8 can recruit SMG-1 to the mRNA surveillance complex and can regulate the kinase activity of SMG-1 [PMID: 19417104].

GO terms

Biological Process

GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.