Transcription factor 7 (IPR028785)

Short name: Tcf7

Overlapping homologous superfamilies


Family relationships


Transcription factor 7 (Tcf7), also referred to by the symbol Tcf1, is a transcriptional activator involved in T-cell lymphocyte differentiation [PMID: 9462507]. It is necessary for the survival of CD4+ CD8+ immature thymocytes [PMID: 11477404]. Tcf7 has multiple isoforms, and there is functional differences between these isoforms [PMID: 7640309, PMID: 8622675].

GO terms

Biological Process

GO:0033153 T cell receptor V(D)J recombination
GO:0060070 canonical Wnt signaling pathway
GO:0006357 regulation of transcription by RNA polymerase II

Molecular Function

GO:0008013 beta-catenin binding

Cellular Component

GO:0005634 nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.