Microtubule-associated serine/threonine-protein kinase 1 (IPR028777)

Short name: MAST1

Overlapping homologous superfamilies


Family relationships



Microtubule-associated serine/threonine-protein kinase 1 (MAST1) belongs to the MAST family, which is characterised by containing a serine/threonine kinase domain and a PDZ (postsynaptic density protein-95/discs large/zona occludens-1) domain [PMID: 18206861]. It links the dystrophin/utrophin network with microtubule filaments via the syntrophins [PMID: 10404183]. MAST1 localises in the DAPC/UAPC, which is found within the postsynaptic region of the neuromuscular junction (NMJ) and central synapses [PMID: 18206861]. The splice variant of its C-terminal affects its subcellular localisation within neurons [PMID: 12614677].

GO terms

Biological Process

GO:0007010 cytoskeleton organization
GO:0035556 intracellular signal transduction

Molecular Function

GO:0004674 protein serine/threonine kinase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.