Transcription factor 7-like (IPR028773)

Short name: TCF7L

Overlapping homologous superfamilies


Family relationships


Transcription factor 7-like 1 (Tcf7L1 or Tcf3) participates in the Wnt signalling pathway [PMID: 9488439]. Tcf3 mediates beta-catenin-induced axis formation [PMID: 8756721, PMID: 9784608, PMID: 12445388, PMID: 15747128].

Transcription factor 7-like 2 (TCF7L2), also known as T-cell-specific transcription factor 4 (Tcf4), also participates in the Wnt signalling pathway [PMID: 16532032]. It is known to control expression of several genes involved in oncogenesis, such as c-jun [PMID: 9990071], c-myc [PMID: 9727977], Cyclin D1 [PMID: 10201372], and many others. TCF7L2 plays an important role for several vital functions in the pancreatic islet [PMID: 18071026] and could have a role in insulin processing [PMID: 17416797].

GO terms

Biological Process

GO:0060070 canonical Wnt signaling pathway
GO:0006357 regulation of transcription by RNA polymerase II

Molecular Function

GO:0008013 beta-catenin binding

Cellular Component

GO:0005634 nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.