Aurora kinase B (IPR028772)

Short name: AURKB

Overlapping homologous superfamilies

Family relationships


Aurora kinase B (AURKB, also known as Aurora 1) is a serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis [PMID: 11516652]. AURKB has various mitotic functions, including chromosome-microtubule interactions, sister chromatid cohesion, the spindle-assembly checkpoint and cytokinesis [PMID: 17848966, PMID: 23616922, PMID: 26528436]. It phosphorylates chromatin proteins such as histone H3 to aid in mitotic chromosome condensation and contributes to the spindle checkpoint [PMID: 24632603]. Its expression is cell cycle-regulated, with a low in G1/S, an increase during G2 and M [PMID: 14722118].

The Aurora kinases are highly conserved serine/threonine kinases that regulate chromosomal alignment and segregation during mitosis and meiosis. Three mammalian Aurora kinases, Aurora A, B and C, have been identified. They all contain a protein kinase domain and a destruction box (D-box) recognised by the multi-subunit E3-ubiquitin ligase anaphase promoting complex/cyclosome (APC/C), which mediates their proteasomal degradation. However, their N-terminal domain share little sequence identity and confer unique protein-protein interaction abilities among the Aurora kinases [PMID: 14625535]. They are differentially expressed at high levels in rapidly dividing tissues such as hematopoietic cells (A and B) and germ cells (C only). Their expression is low or absent in most adult tissues due to their lower rates of proliferation [PMID: 24632603].

GO terms

Biological Process

GO:0043988 histone H3-S28 phosphorylation
GO:0007094 mitotic spindle assembly checkpoint
GO:0032467 positive regulation of cytokinesis

Molecular Function

GO:0004674 protein serine/threonine kinase activity

Cellular Component

GO:0032133 chromosome passenger complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.