Pathways & interactions
Tyrosine-protein phosphatase non-receptor type 23 (IPR028770)
Short name: PTPN23
Tyrosine-protein phosphatase non-receptor type 23 (PTPN23, also known as HD-PTP) is a non-transmembrane protein tyrosine phosphatase. It plays a role in sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) via its interaction with the ESCRT-I complex (endosomal sorting complex required for transport I), and possibly also other ESCRT complexes [PMID: 18434552, PMID: 23477725]. It also contributes to the signal transduction pathways involved in the regulation of cell migration and invasion [PMID: 21724833, PMID: 22510412] and has been shown to play a role in ciliogenesis [PMID: 2039356].
GO:0004725 protein tyrosine phosphatase activity
No terms assigned in this category.
- PTHR19134:SF333 (PTHR19134:SF333)