Tyrosine-protein phosphatase non-receptor type 23 (IPR028770)

Short name: PTPN23

Overlapping homologous superfamilies


Family relationships



Tyrosine-protein phosphatase non-receptor type 23 (PTPN23, also known as HD-PTP) is a non-transmembrane protein tyrosine phosphatase. It plays a role in sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) via its interaction with the ESCRT-I complex (endosomal sorting complex required for transport I), and possibly also other ESCRT complexes [PMID: 18434552, PMID: 23477725]. It also contributes to the signal transduction pathways involved in the regulation of cell migration and invasion [PMID: 21724833, PMID: 22510412] and has been shown to play a role in ciliogenesis [PMID: 2039356].

GO terms

Biological Process

GO:0060271 cilium assembly
GO:0030334 regulation of cell migration
GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

Molecular Function

GO:0004725 protein tyrosine phosphatase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.