Kelch repeat and BTB domain-containing protein 8 (IPR028764)

Short name: KBTBD8

Overlapping homologous superfamilies

Family relationships

  • BTB-kelch protein (IPR017096)
    • Kelch repeat and BTB domain-containing protein 8 (IPR028764)


Kelch repeat and BTB domain-containing protein 8 (KBTBD8) belongs to the BTB-kelch protein family. KBTBD8 localises in the Golgi apparatus and translocates to the spindle apparatus during mitosis [PMID: 23578279]. Its function is still not clear.

The BTB superfamily includes KLHL (Kelch-like), KBTBD (Kelch repeat and BTB domain-containing), and KLHDC (Kelch domain-containing) subfamilies, which encompass structurally related molecules that differ in the types and numbers of their protein domains. The domain composition can appear to vary depending on the protein domain prediction program. For example, KLHL29, KLHL31, KLHL40, and KLHL41 were previously assigned within the KBTBD family as KBTBD9, KBTBD1, KBTBD5, and KBTBD10 respectively. KBTBD proteins have typically one BTB/POZ domain, occasionally a BACK domain, and two to four Kelch motifs [PMID: 23676014].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.