Ski oncogene (IPR028760)

Short name: Ski

Overlapping homologous superfamilies


Family relationships


Ski is involved in oncogenic transformation and enhancement of muscle differentiation by blocking TGF-beta signaling [PMID: 19049980, PMID: 7659522]. Ski binds directly to the Smad3/4 complex and negatively regulates TGF-beta signaling [PMID: 10575014, PMID: 11278756, PMID: 12419246]. It plays a role in terminal differentiation of skeletal muscle cells, but not in the determination of cells to the myogenic lineage [PMID: 12874272]. Ski is a component of the histone deacetylase complex (HDAC) complex and is required for the transcriptional repression mediated by this complex [PMID: 10049357].

This entry includes v-ski (viral oncogene ski) from the avian Sloan-Kettering retroviruses and its homologue from animals, c-ski [PMID: 1870207]. c-ski can promote cancer progression and is highly expressed in some of solid cancers including leukemia, melanoma, colorectal cancer, gastric cancer and pancreatic cancer [PMID: 24011664]. However, it can also act as a tumour suppressor in some cases [PMID: 24011664].

GO terms

Biological Process

GO:0006351 transcription, DNA-templated

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.