Family

Ski oncogene (IPR028760)

Short name: Ski

Family relationships

Description

Ski is involved in oncogenic transformation and enhancement of muscle differentiation by blocking TGF-beta signaling [PMID: 19049980, PMID: 7659522]. Ski binds directly to the Smad3/4 complex and negatively regulates TGF-beta signaling [PMID: 10575014, PMID: 11278756, PMID: 12419246]. It plays a role in terminal differentiation of skeletal muscle cells, but not in the determination of cells to the myogenic lineage [PMID: 12874272]. Ski is a component of the histone deacetylase complex (HDAC) complex and is required for the transcriptional repression mediated by this complex [PMID: 10049357].

This entry includes v-ski (viral oncogene ski) from the avian Sloan-Kettering retroviruses and its homologue from animals, c-ski [PMID: 1870207]. c-ski can promote cancer progression and is highly expressed in some of solid cancers including leukemia, melanoma, colorectal cancer, gastric cancer and pancreatic cancer [PMID: 24011664]. However, it can also act as a tumour suppressor in some cases [PMID: 24011664].

GO terms

Biological Process

GO:0006351 transcription, DNA-templated

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER