Family

Tissue alpha-L-fucosidase (IPR028755)

Short name: FUCA1

Overlapping homologous superfamilies

Family relationships

Description

Alpha-L-fucosidase is responsible for hydrolysing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins. In humans, this enzyme is encoded by two genes: FUCA1, which codes the tissue enzyme, and FUCA2, which leads to plasma alpha-L-fucosidase [PMID: 17175120]. The significance of tissue alpha-L-fucosidase in metabolism is shown in the genetic neurovisceral storage disease fucosidosis, caused by a defect of the FUCA1 gene [PMID: 17427030, PMID: 9762612].

This entry represents the tissue alpha-L-fucosidase (FUCA1).

GO terms

Biological Process

GO:0005975 carbohydrate metabolic process

Molecular Function

GO:0004560 alpha-L-fucosidase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER