Serine/threonine-protein kinase PAK5 (IPR028754)

Short name: PAK5

Overlapping homologous superfamilies


Family relationships



Serine/threonine-protein kinase PAK 5 (PAK5, also known as PAK7) belongs to the mammalian p21-activated kinase (PAK) family of serine/threonine kinases that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, proliferation or cell survival [PMID: 11756552].

PAK5 (PAK7) induces filopodia formation and neurite outgrowth in neuroblastoma cells, perhaps through the Cdc42/Rac pathway [PMID: 11756552]. It is an inhibitor of the MARK2 kinase, which leads to stable microtubules and dynamic actin [PMID: 16014608]. It also has functions in apoptosis [PMID: 12897128], MAP Kinase pathway [PMID: 18465753] and cancer malignant progression [PMID: 19415746].

GO terms

Biological Process

GO:0006915 apoptotic process
GO:0016049 cell growth
GO:0007010 cytoskeleton organization

Molecular Function

GO:0004674 protein serine/threonine kinase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.